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Our publications

Riegger J and Brenner R. Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes. Elife. (accepted manuscript; 04.10.2023; preprint: Riegger J, Schoppa A, Ruths L, Haffner-Luntzer M, Ignatius A. Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review. Cell Mol Biol Lett. 2023, 28(1):76. doi: 10.1186/s11658-023-00489-y. Teixeira GQ, Riegger J, Goncalves RM, Risbud MV. Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair. Front Bioeng Biotechnol 2023. Kuhn A, Riegger J, Teixeira GQ, Huber-Lang M, Lambris JD, Neidlinger-Wilke C, Brenner RE. Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells. Cells 2023, 12(6), 887; Riegger J, Joos H, Möhler V, Leucht F, Rading K, Kubisch C, Ignatius A, Huber-Lang M, Brenner RE. Functional Loss of terminal complement complex protects rabbits from injury-in- duced osteoarthritis on structural and cellular level. Biomolecules. 2023, 13(2), 216. Riegger J. TRPV1 as an anti-ferroptotic target in osteoarthritis. eBioMedicine. 2022, 84: 104279. (invited comment) Riegger J, Svenja M, Pulasani S, and Brenner RE. Simvastatin and Fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage. Front Bioeng Biotechnol 10:965302. doi: 10.3389/fbioe.2022.965302 Kirsch V, Ramge J-M, Schoppa A, Ignatius A, Riegger J. In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes. Cells. 2022, 11(7): 1106. Schoppa  A, Chen  X, Ramge J-M, Vikman A, Fischer V, Haffner-Luntzer M, Riegger J, Tuckermann J, Scharffetter-Kochanek K, Ignatius A. Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. Dis Model Mech. 2022, 15(5):dmm049392. doi: 10.1242/dmm.049392. Riegger J, Baumert J, Zaucke F, Brenner RE. The hexosamine biosynthetic pathway as therapeutic target in posttraumatic osteoarthritis: Modification of chondrocyte survival and metabolism by glucosamine derivatives and PUGNAc after ex vivo cartilage trauma. Int J Mol Sci. 2021, 22(14), 7247; Teixeira GQ, Yong Z, Kuhn A, Riegger J, Goncalves RM, Ruf M, Mauer UM, Huber-Lang M, Ignatius A, Brenner RE, Neidlinger-Wilke C. Interleukin-1β and cathepsin D modulate formation of the terminal complement complex formation in cultured human disc tissue. Eur Spine J. 2021, doi: 10.1007/s00586-021-06901-5. Herrmann M, Diederichs S, Melnik S, Riegger J, Trivanović D, Li S, Jenei-Lanzl Z, Brenner RE, Huber-Lang M, Zaucke F, Schildberg F, Grässel S. Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration. Front Bioeng Biotechnol. Teixeira G, Yong Z, Goncalves R, Kuhn A, Riegger J, Brisby H, Henriksson H, Ruf M, Nerlich A, Mauer U, Ignatius A, Brenner RE, Neidlinger-Wilke C. Terminal complement complex formation is associated with intervertebral disc degeneration. Eur Spine J. 2020, Riegger J, Huber-Lang M, Brenner RE. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. Osteoarthritis Cartilage. 2020; 28(5):685-697. Riegger J, Brenner RE. Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment. Int J Mol Sci. 2020, 21:1560. Riegger J, Rehm M, Büchele G, Brenner H, Günther KP, Rothenbacher D, Brenner RE. Serum cartilage oligomeric matrix protein in late-stage osteoarthritis: Association with clinical features, renal function and cardiovascular biomarkers. J Clin Med. 2020, 18;9(1). Riegger J, Brenner R. Evidence of necroptosis in osteoarthritic disease: Investigation of blunt mechanical impact as possible trigger in regulated necrosis. Cell Death Dis. 2019, 10:683. Maly K, Schaible I, Riegger J, Brenner RE, Meurer A, Zaucke, F. The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage. Int J Mol Sci. 2019, 20(2): 447. Riegger J, Leucht F, Palm HG, Ignatius A, Brenner RE. Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo. Int J Mol Sci. 2019, 20(12), 2916. Riegger J, Palm HG, Brenner RE. The functional role of chondrogenic stem/ progenitor cells: Novel evidence for immunomodulatory properties and regenerative potentials after cartilage injury. Eur Cell Mater. 2018, 36:110-127. Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma. J Cell Mol Med. 2018, 22(1):77-88.     Riegger J, Zimmermann M, Joos H, Kappe T, Brenner RE. Hypothermia promotes cell- & chondro- protective effects after blunt cartilage trauma. Am J Sports Med. 2018, 46(2):420-430.  Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine. Osteoarthritis Cartilage. 2016, 24(12):2171-2180.  Joos H, Leucht F, Riegger J, Hogrefe C, Fiedler J, Dürselen L, Reichel H, Ignatius A, Brenner RE. Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo. Am J Sports Med. 2015, 43:2822-2832.

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