Kirsch V, Ramge J-M, Schoppa A, Ignatius A, Riegger J. In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes. Cells. 2022, 11(7): 1106. Schoppa  A, Chen  X, Ramge J-M, Vikman A, Fischer V, Haffner-Luntzer M, Riegger J, Tuckermann J, Scharffetter-Kochanek K, Ignatius A. Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. Dis Model Mech. 2022, 15(5):dmm049392. doi: 10.1242/dmm.049392. Riegger J, Baumert J, Zaucke F, Brenner RE. The hexosamine biosynthetic pathway as therapeutic target in posttraumatic osteoarthritis: Modification of chondrocyte survival and metabolism by glucosamine derivatives and PUGNAc after ex vivo cartilage trauma. Int J Mol Sci. 2021, 22(14), 7247; https://doi.org/10.3390/ijms22147247. Teixeira GQ, Yong Z, Kuhn A, Riegger J, Goncalves RM, Ruf M, Mauer UM, Huber-Lang M, Ignatius A, Brenner RE, Neidlinger-Wilke C. Interleukin-1β and cathepsin D modulate formation of the terminal complement complex formation in cultured human disc tissue. Eur Spine J. 2021, doi: 10.1007/s00586-021-06901-5. Herrmann M, Diederichs S, Melnik S, Riegger J, Trivanović D, Li S, Jenei-Lanzl Z, Brenner RE, Huber-Lang M, Zaucke F, Schildberg F, Grässel S. Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration. Front Bioeng Biotechnol. https://doi.org/10.3389/fbioe.2020.624096. Teixeira G, Yong Z, Goncalves R, Kuhn A, Riegger J, Brisby H, Henriksson H, Ruf M, Nerlich A, Mauer U, Ignatius A, Brenner RE, Neidlinger-Wilke C. Terminal complement complex formation is associated with intervertebral disc degeneration. Eur Spine J. 2020, https://doi.org/10.1007/s00586-020-06592-4. Riegger J, Huber-Lang M, Brenner RE. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. Osteoarthritis Cartilage. 2020; 28(5):685-697. https://doi.org/10.1016/j.joca.2020.01.004. Riegger J, Brenner RE. Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment. Int J Mol Sci. 2020, 21:1560. https://www.mdpi.com/1422-0067/21/5/1560. Riegger J, Rehm M, Büchele G, Brenner H, Günther KP, Rothenbacher D, Brenner RE. Serum cartilage oligomeric matrix protein in late-stage osteoarthritis: Association with clinical features, renal function and cardiovascular biomarkers. J Clin Med. 2020, 18;9(1). https://www.mdpi.com/2077-0383/9/1/268. Riegger J, Brenner R. Evidence of necroptosis in osteoarthritic disease: Investigation of blunt mechanical impact as possible trigger in regulated necrosis. Cell Death Dis. 2019, 10:683. https://www.nature.com/articles/s41419-019-1930-5. Maly K, Schaible I, Riegger J, Brenner RE, Meurer A, Zaucke, F. The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage. Int J Mol Sci. 2019, 20(2): 447. https://www.mdpi.com/1422-0067/20/2/447. Riegger J, Leucht F, Palm HG, Ignatius A, Brenner RE. Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo. Int J Mol Sci. 2019, 20(12), 2916. https://www.mdpi.com/1422-0067/20/12/2916. Riegger J, Palm HG, Brenner RE. The functional role of chondrogenic stem/ progenitor cells: Novel evidence for immunomodulatory properties and regenerative potentials after cartilage injury. Eur Cell Mater. 2018, 36:110-127. https://www.ecmjournal.org/papers/vol036/pdf/v036a09.pdf. Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma. J Cell Mol Med. 2018, 22(1):77-88. https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.13295.     Riegger J, Zimmermann M, Joos H, Kappe T, Brenner RE. Hypothermia promotes cell- & chondro- protective effects after blunt cartilage trauma. Am J Sports Med. 2018, 46(2):420-430. https://journals.sagepub.com/doi/10.1177/0363546517736051.  Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine. Osteoarthritis Cartilage. 2016, 24(12):2171-2180. https://www.oarsijournal.com/article/S1063-4584(16)30211-4/fulltext.  Joos H, Leucht F, Riegger J, Hogrefe C, Fiedler J, Dürselen L, Reichel H, Ignatius A, Brenner RE. Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo. Am J Sports Med. 2015, 43:2822-2832. https://journals.sagepub.com/doi/10.1177/0363546515602248.