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Our publications

1.) Original articles:

  1. Riegger J and Geiger H. Protocol to quantify cell-surface vimentin on senescent human chondrocytes and other cell types via a cell-based ELISA. Star Protoc. 2026, 7(2):104451. https://doi.org/10.1016/j.xpro.2026.104451
     

  2. Marques SS*, Liebaug A*, Maurer S, Rothenbacher D, Brenner RE, Riegger J. Growth/Differentiation Factor 15 Promotes a Pro-Regenerative Response in Chondrocytes Upon Cartilage Injury. MedComm. 2025, 6(12):e70484. doi:10.1002/mco2.70484.
     

  3. Schmid T, Kanewska A, Lam C, Kalbitz M, Dieterich S, Ignatius A, Riegger J, Giger NV, Wehrle E, Marcucio RS, Miclau T, Haffner-Luntzer M. Influence of Age on Fracture Healing in Young and Middle-Aged Mice in a Proximal Femur Fracture Model. J Orthop Res. 2025; 43(12):2233-2246. doi: 10.1002/jor.70063. 
     

  4. Ruths L, de Hesselle H, Haußner F, Albers S, Harms M, Freitag T, Münch J, Riegger J. Targeting the CXCL12/CXCR4 pathway by an optimized derivative or EPI-X4 preserves chondrocyte function and offers a novel therapeutic approach in rheumatic diseases. Arthritis Res Ther. 2025, 27(1):222. doi: 10.1186/s13075-025-03691-9.
     

  5. Ruths L, Hengge J, Teixeira GQ, Haffner-Luntzer M, Ignatius A, Riegger J. Terminal complement complex deposition on chondrocytes promotes premature senescence in age-and trauma-related osteoarthritis. Front Immunol. 2024, 15:1470907.doi: 10.3389/fimmu.2024.1470907.
     

  6. Maurer S, Fuchs M, Brenner RE, Riegger J. Glutathione has cell protective and anti-catabolic effects in articular cartilage without impairing the chondroanabolic phenotype. Heliyon. 2024, 10(22):e40368. doi: 10.1016/j.heliyon.2024.e40368.
     

  7. Kuhn A, Huber-Lang M, Weckbach S, Riegger J, Teixeira GQ, Rasche V, Fiedler J, Neidlinger-Wilke C, Brenner RE. Analysis of Intervertebral Disc Degeneration Induced by Endplate Drilling or Needle Puncture in Complement C6-Sufficient and C6-Deficient Rabbits. Biomolecules. 2024, 12(8), 1692. doi: 10.3390/biomedicines12081692.
     

  8. Maurer S, Kirsch V, Ruths L, Brenner RE, Riegger J. Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators. Aging Cell. 2025,24(1):e14361. doi: 10.1111/acel.14361.
     

  9. Ruths L, Huber-Lang M, Schulze-Tanzil G, Riegger J. Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression. Osteoarthritis Cartilage. 2024, 32(5):514-525. doi: 10.1016/j.joca.2024.01.004.
     

  10. Riegger J and Brenner R. Increase of cell surface vimentin is associated with vimentin network disruption and subsequent stress-induced premature senescence in human chondrocytes. Elife. 2023, 12:e91453. doi: 10.7554/eLife.91453
     

  11. Riegger J*, Joos H*, Möhler V, Leucht F, Rading K, Kubisch C, Ignatius A, Huber-Lang M, Brenner RE. Functional Loss of terminal complement complex protects rabbits from injury-induced osteoarthritis on structural and cellular level. Biomolecules. 2023, 13(2), 216. 
     

  12. Kuhn A, Riegger J, Teixeira GQ, Huber-Lang M, Lambris JD, Neidlinger-Wilke C, Brenner RE. Terminal Complement Activation Is Induced by Factors Released from Endplate Tissue of Disc Degeneration Patients and Stimulates Expression of Catabolic Enzymes in Annulus Fibrosus Cells. Cells 2023, 12(6), 887; doi: 10.3390/cells12060887 
     

  13. Schoppa A, Chen X, Ramge J-M, Vikman A, Fischer V, Haffner-Luntzer M, Riegger J, Tuckermann J, Scharffetter-Kochanek K, Ignatius A. Osteoblast lineage Sod2 deficiency leads to an osteoporosis-like phenotype in mice. Dis Model Mech. 2022, 15(5):dmm049392. Doi: 10.1242/dmm.049392. 
     

  14. Riegger J, Svenja M, Pulasani S, and Brenner RE. Simvastatin and Fluvastatin attenuate trauma-induced cell death and catabolism in human cartilage. Front Bioeng Biotechnol 2022, 10:965302. doi: 10.3389/fbioe.2022.965302 
     

  15. Kirsch V, Ramge J-M, Schoppa A, Ignatius A, Riegger J. In Vitro Characterization of Doxorubicin-Mediated Stress-Induced Premature Senescence in Human Chondrocytes. Cells. 2022, 11(7): 1106. doi: 10.3390/cells11071106.
     

  16. Riegger J, Baumert J, Zaucke F, Brenner RE. The hexosamine biosynthetic pathway as therapeutic target in posttraumatic osteoarthritis: Modification of chondrocyte survival and metabolism by glucosamine derivatives and PUGNAc after ex vivo cartilage trauma. Int J Mol Sci. 2021, 22(14), 7247; doi: 10.3390/ijms22147247.
     

  17. Teixeira GQ, Yong Z, Kuhn A, Riegger J, Goncalves RM, Ruf M, Mauer UM, Huber-Lang M, Ignatius A, Brenner RE, Neidlinger-Wilke C. Interleukin-1β and cathepsin D modulate formation of the terminal complement complex formation in cultured human disc tissue. Eur Spine J. 2021, doi: 10.1007/s00586-021-06901-5.     
     

  18. Teixeira G, Yong Z, Goncalves R, Kuhn A, Riegger J, Brisby H, Henriksson H, Ruf M, Nerlich A, Mauer U, Ignatius A, Brenner RE, Neidlinger-Wilke C. Terminal complement complex formation is associated with intervertebral disc degeneration. Eur Spine J. 2020, doi: 10.1007/s00586-020-06592-4   
     

  19. Riegger J, Huber-Lang M, Brenner RE. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma. Osteoarthritis Cartilage. 2020; 28(5):685-697. Doi: 10.1016/j.joca.2020.01.004
     

  20. Riegger J*, Rehm M*, Büchele G, Brenner H, Günther KP, Rothenbacher D, Brenner RE. Serum cartilage oligomeric matrix protein in late-stage osteoarthritis: Association with clinical features, renal function and cardiovascular biomarkers. J Clin Med. 2020, 18;9(1). https://www.mdpi.com/2077-0383/9/1/268.
     

  21. Riegger J, Brenner RE. Evidence of necroptosis in osteoarthritic disease: Investigation of blunt mechanical impact as possible trigger in regulated necrosis. Cell Death Dis. 2019, 10:683. https://www.nature.com/articles/s41419-019-1930-5.  
     

  22. Riegger J, Leucht F, Palm HG, Ignatius A, Brenner RE. Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo. Int J Mol Sci. 2019, 20(12), 2916. https://www.mdpi.com/1422-0067/20/12/2916. 
     

  23. Maly K, Schaible I, Riegger J, Brenner RE, Meurer A, Zaucke, F. The Expression of Thrombospondin-4 Correlates with Disease Severity in Osteoarthritic Knee Cartilage. Int J Mol Sci. 2019, 20(2): 447. doi: 10.3390/ijms20020447.
     

  24. Riegger J, Palm HG, Brenner RE. The functional role of chondrogenic stem/ progenitor cells: Novel evidence for immunomodulatory properties and regenerative potentials after cartilage injury. Eur Cell Mater. 2018, 36:110-127. https://www.ecmjournal.org/papers/vol036/pdf/v036a09.pdf.
     

  25. Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma. J Cell Mol Med.2018, 22(1):77-88. https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.13295.
     

  26. Riegger J, Zimmermann M, Joos H, Kappe T, Brenner RE. Hypothermia promotes cell- & chondro- protective effects after blunt cartilage trauma. Am J Sports Med. 2018, 46(2):420-430. doi: 10.1177/0363546517736051.          
     

  27. Riegger J, Joos H, Palm HG, Friemert B, Reichel H, Ignatius A, Brenner RE. Antioxidative therapy in an ex vivo human cartilage trauma-model: attenuation of trauma-induced cell loss and ECM-destructive enzymes by N-acetyl cysteine. Osteoarthritis Cartilage. 2016, 24(12):2171-2180. doi: 10.1016/j.joca.2016.07.019.
     

  28. Joos H, Leucht F, Riegger J, Hogrefe C, Fiedler J, Dürselen L, Reichel H, Ignatius A, Brenner RE. Differential Interactive Effects of Cartilage Traumatization and Blood Exposure In Vitro and In Vivo. Am J Sports Med. 2015, 43:2822-2832. doi: 10.1177/0363546515602248.

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2.) Review articles/ Invited comments/ Editorials
 

  1. Jenei-Lanzl Z*, Maurer S*, Brenner RE, Zaucke F, Fuchs M, Riegger J. Emerging concepts and challenges in the development of disease-modifying osteoarthritis drugs - a more refined perspective. Arch Pharm Res. 2025, 48(6):467-494. doi: 10.1007/s12272-025-01551-3.
     

  2. Riegger J, Schoppa A, Ruths L, Haffner-Luntzer M, Ignatius A. Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review. Cell Mol Biol Lett. 2023, 28(1):76. doi: 10.1186/s11658-023-00489-y. 
     

  3. Riegger J, Brenner RE. Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment. Int J Mol Sci. 2020, 21:1560. doi: 10.3390/ijms21051560.
     

  4. Herrmann M, Diederichs S, Melnik S, Riegger J, Trivanović D, Li S, Jenei-Lanzl Z, Brenner RE, Huber-Lang M, Zaucke F, Schildberg F, Grässel S. Extracellular Vesicles in Musculoskeletal Pathologies and Regeneration. Front Bioeng Biotechnol. doi: 10.3389/fbioe.2020.624096 
     

  5. Graciosa GQ, Riegger J, Gonçalves MR, Risbud MV. Editorial: Intervertebral disc degeneration and osteoarthritis: mechanisms of disease and functional repair. Front Bioeng Biotechnol. 2023, 11:1252703. doi: 10.3389/fbioe.2023.1252703. eCollection 2023 
     

  6. Riegger J. Comment on: TRPV1 as an anti-ferroptotic target in osteoarthritis. eBioMedicine. 2022, 84: 104279. https://doi.org/10.1016/j.ebiom.2022.104279.

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